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Report: Real Madrid could be without four key players against Tottenham

Spain's midfielder Isco celebrates with Sergio Ramos (R) after scoring the second goal during the FIFA 2018 World Cup Qualifier between Spain and I...
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Tottenham Hotspur take on the Spanish side in the Champions League this week.

Isco Alarcon of Spain gets away from Taulant Xhaka of Albania during the FIFA 2018 World Cup Qualifier between Spain and Albania at Estadio Jose Rico Perez on October 6, 2017 in Alicante,...

According to FourFourTwo, Real Madrid could be severely depleted for their Champions League group clash against Tottenham Hotspur on Wednesday evening.

The two sides drew 1-1 in the reverse fixture earlier this month and now Tottenham have the chance to take all three points at Wembley, securing their place in the knockout stages in the process.

Gareth Bale of Real Madrid CF walks onto the pitch prior to the La Liga match between Real Sociedad and Real Madrid at Anoeta stadium on September 17, 2017 in San Sebastian, Spain.

And their hopes could be helped with a number of top Madrid players struggling to be fit for the game, with the latest report suggesting that Gareth Bale, Isco, Raphael Varane and Keylor Navas all doubtful for the clash.

Bale has been training on his own ahead of the fixture against his former side and there are hopes among the Madrid hierarchy that he will be back in time, but the prospect of Real being without some of their key men will surely be music to Mauricio Pochettino’s ears.

Harry Kane of Tottenham Hotspur shoots and Raphael Varane of Real Madrid deflects his shot into the net for Tottenham Hotspur first goal during the UEFA Champions League group H match...

The likely return of Harry Kane for Tottenham will be another big boost for their manager and it will be interesting to see how the respective sides line up later this week.

Real have the players to cope with a mini injury crisis but it will certainly give Tottenham an advantage if they cannot call on four regular starters.