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Predicted Tottenham line-up: Pochettino makes five changes, Davies misses out

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Tottenham Hotspur take on Southampton on Wednesday night.

Mauricio Pochettino, Manager of Tottenham Hotspur during the Premier League match between Arsenal FC and Tottenham Hotspur at Emirates Stadium on December 2, 2018 in London, United Kingdom.

Tottenham Hotspur take on Southampton in the Premier League on Wednesday night, with Mauricio Pochettino facing a number of selection issues.

Spurs were thumped 4-2 by bitter North London rivals Arsenal on Sunday afternoon, and boss Pochettino must now consider changes to his side.

Hugo Lloris will almost certainly keep his place in goal despite leaking four at the Emirates Stadium, with Paulo Gazzaniga unlikely to dislodge the Frenchman.

Kieran Trippier is back in training and available to play, and having given Serge Aurier three starts in a row, it may be time for Trippier to come back in.

Jan Vertonghen is suspended and Davinson Sanchez injured, meaning Toby Alderweireld and Juan Foyth should start at centre back, whilst Danny Rose should come in at left back.

Lucas Moura of Tottenham Hotspur during the Group B match of the UEFA Champions League between Tottenham Hotspur and PSV at Wembley Stadium on November 6, 2018 in London, United Kingdom.

Eric Dier may keep his place but Harry Winks will surely join him in midfield, with Son Heung-min, Christian Eriksen and Harry Kane keeping their spots in attack.

Lucas Moura should come in on the right having been a substitute against Arsenal, which would mean Dele Alli drops out of the side alongside Aurier, Vertonghen, Ben Davies and Moussa Sissoko in five changes for Spurs.

Tottenham v Southampton