Sheffield Wednesday will face Carlisle United in the FA Cup third-round replay on Tuesday.
The former Celtic and Arsenal forward believes that Championship club Wednesday will win the game against League Two side Carlisle 3-0.
Nicholas has also backed Wednesday striker Jordan Rhodes to score the opening goal of the match.
The Scotland international is a proven goalscorer in the Championship, but the performances of the former Huddersfield Town and Middlesbrough striker so far this season have not been great.
Rhodes has scored just four goals and provided only one assist in 1217 minutes of Championship football for the Owls so far this campaign, according to WhoScored.
The 27-year-old striker joined Wednesday on loan from Middlesbrough in January 2017 for the rest of the 2016-17 campaign and signed a permanent contract with the Owls in the summer of 2017 for a transfer fee reported by Gazette Live to be worth £10 million.
Nicholas wrote on Skysports.com: “This was my tip for a surprise in the last round, but Wednesday managed to get a replay despite failing to score yet again.
“Jos Luhukay will be looking to build on a positive result in the Steel City derby and I think he will play the strongest team to get a result.”
A footnote added: “Charlie predicts: 3-0 and Jordan Rhodes to score first.”
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