Arsenal starting XI: Ramsdale; Tomiyasu, White, Gabriel, Tierney; Partey, Xhaka; Saka, Odegaard, Smith Rowe; Aubameyang.
Arsenal substitutes: Leno, Holding, Cedric, Tavares, Lokonga, Maitland-Niles, Martinelli, Pepe, Lacazette.
Tottenham Hotspur starting XI: Lloris; Tanganga, Sanchez, Dier, Reguilon; Hojbjerg, Alli, Ndombele; Lucas, Son, Kane.
Tottenham Hotspur substitutes: Gollini, Emerson, Romero, Davies, Rodon, Skipp, Lo Celso, Bryan, Scarlett.
Arsenal go with Aaron Ramsdale in goal having seen him displace Bernd Leno.
Takehiro Tomiyasu and Kieran Tierney are the full backs, with Ben White and Gabriel Magalhaes at centre back.
Granit Xhaka returns in midfield alongside Thomas Partey, with Martin Odegaard as the number 10.
Bukayo Saka and Emile Smith Rowe are out wide, with Pierre-Emerick Aubameyang up top.
Nicolas Pepe drops to the bench, joining Bernd Leno, Cedric Soares, Rob Holding, Nuno Tavares, Albert Sambi Lokonga, Ainsley Maitland-Niles, Gabriel Martinelli and Alexandre Lacazette.
Tottenham have Hugo Lloris between the sticks, which a couple of changes at the back.
Japhet Tanganga and Davinson Sanchez come into the side, replacing Emerson Royal and Cristian Romero.
Eric Dier and Sergio Reguilon also start, with Pierre-Emile Hojbjerg in front of the back four.
Tanguy Ndombele and Dele Alli both feature in midfield, with Lucas Moura straight into the side.
The Brazilian is back after injury, joining Son Heung-min and Harry Kane in attack.
Romero and Emerson are on the bench, joining Pierluigi Gollini, Ben Davies, Joe Rodon, Oliver Skipp, Giovani Lo Celso, Bryan Gil and Dane Scarlett.