Tottenham Hotspur starting XI: Lloris; Aurier, Alderweireld, Dier, Reguilon; Hojbjerg, Sissoko, Ndombele; Bergwijn, Son, Kane.
Tottenham Hotspur substitutes: Hart, Davies, Rodon, Lo Celso, Bale, Lucas, Vinicius.
Manchester City starting XI: Ederson; Walker, Dias, Laporte, Cancelo; Rodrigo, De Bruyne, Bernardo; Mahrez, Torres, Jesus.
Manchester City substitutes: Steffen, Stones, Sterling, Gundogan, Aguero, Foden, Garcia.
Tottenham Hotspur go with Hugo Lloris in goal, behind a back four Serge Aurier, Toby Alderweireld, Eric Dier and Sergio Reguilon.
Pierre-Emile Hojbjerg will protect the back four, with added support from Moussa Sissoko and Tanguy Ndombele in the engine room.
Steven Bergwijn is handed a surprise start on the right, with Son Heung-min and Harry Kane making up the rest of the front three.
Gareth Bale is therefore only on the bench, alongside Joe Hart, Ben Davies, Joe Rodon, Giovani Lo Celso, Lucas Moura and Carlos Vinicius.
Meanwhile, Manchester City have Ederson between the sticks, with Kyle Walker, Ruben Dias, Aymeric Laporte and Joao Cancelo making up the back four.
Rodrigo featured in midfield alongside Kevin De Bruyne and Bernardo Silva in an attack-minded lineup, behind the front three of Riyad Mahrez, Ferran Torres and Gabriel Jesus.
Sergio Aguero and Raheem Sterling are only on the bench, joining Zach Steffen, John Stones, Ilkay Gundogan, Phil Foden and Eric Garcia.