Spurs will take on Newcastle at Tottenham Hotspur Stadium in the Premier League on Sunday afternoon.
The North London club were in action in the Europa League qualifying on Thursday evening.
Ndombele started the match and played for the entire 90 minutes, and Mourinho has suggested that the 23-year-old France international midfielder will not start against the Magpies.
Mourinho told The Guardian about Ndombele: “Can he play on Sunday against Newcastle? I’m not sure. It’s the first time he played 90 minutes.
“Premier League matches are much more difficult than this one against Shkendija. But against Southampton, even for 45 minutes, Tanguy had positive things.”
Ndombele played well in parts for Tottenham last season, and it must be noted that he had injury problems.
The France international is a very good player who will be an important figure in the current Tottenham team this season.
It is only the start of the new season, and Spurs have a very busy schedule ahead, and it makes sense for Mourinho to give Ndombele rest from time to time.
Jesse Lingard situation
Meanwhile, Sky Sports have reported that Manchester United player Jesse Lingard’s agents have held ‘initial talks with several clubs in England and Europe’.
The report has claimed that the England international – who can play as an attacking midfielder or as a winger – will be allowed to decide his own future.
According to The Daily Star, Tottenham are planning to sign the 27-year-old England international in a £30 million deal.