Southampton starting XI: McCarthy; Valery, Bednarek, Stephens, Bertrand; Hojbejrg, Ward-Prowse, Armstrong, Redmond; Obafemi, Ings.
Southampton substitutes: Gunn, Walker-Peters, Vestergaard, Vokins, Romeu, Smallbone, Tella, Long, Adams.
Arsenal starting XI: Martinez; Bellerin, Mustafi, Holding, Tierney; Xhaka, Ceballos, Saka; Pepe, Aubameyang, Nketiah.
Arsenal substitutes: Macey, Sokratis, Kolasinac, Maitland-Niles, Willock, Smith, Nelson, Ozil, Lacazette.
Southampton start with Alex McCarthy between the sticks, behind a back four of Yan Valery, Jan Bednarek, Jack Stephens and Ryan Bertrand.
Pierre-Emile Hojbjerg partners James Ward-Prowse in midfield, with Stuart Armstrong and Nathan Redmond supporting the front two of Michael Obafemi and Danny Ings.
Tottenham loanee Kyle Walker-Peters is on the bench, alongside Angus Gunn, Jannik Vestergaard, Jake Vokins, Oriol Romeu, William Smallbone, Nathan Tella, Che Adams and Shane Long.
Meanwhile, Emiliano Martinez starts in goal for Arsenal, taking the place of injured stopper Bernd Leno.
Hector Bellerin, Shkodran Mustafi, Rob Holding and Kieran Tierney back up the back four, with Granit Xhaka in front of them.
Dani Ceballos and Bukayo Saka should have more freedom to go forward, supporting the three-man attack of Nicolas Pepe, Eddie Nketiah and Pierre-Emerick Aubameyang.
Matteo Guendouzi isn’t even on the bench after his incident at Brighton last weekend, but youngster Matt Smith is given a spot as a substitute.
He is joined by Matt Macey, Sokratis Papastathopoulos, Sead Kolasinac, Ainsley Maitland-Niles, Joe Willock, Reiss Nelson, Mesut Ozil and Alexandre Lacazette.