United start with David De Gea between the sticks, and he will be protected by Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire and Ashley Young.
Scott McTominay is available to start in midfield, joining Fred in front of the back four, with Daniel James and Mason Greenwood out wide.
Jesse Lingard will operate behind Marcus Rashford, with Anthony Martial ruled out for tonight's game.
Andreas Pereira is dropped to the bench, joining Sergio Romero, Axel Tuanzebe, Luke Shaw, Brandon Williams, James Garner and Juan Mata.
Meanwhile, Tottenham once again go with Paulo Gazzaniga in goal, with Hugo Lloris still not back from an elbow injury.
Serge Aurier, Toby Alderweireld and Davinson Sanchez continue in the back four, with Jan Vertonghen again trusted at left back.
Harry Winks partners Moussa Sissoko in midfield, with Lucas Moura, Dele Alli and Son Heung-min supporting Harry Kane in the final third.
That means that Tanguy Ndombele is on the bench, alongside Brandon Austin, Danny Rose, Juan Foyth, Eric Dier, Christian Eriksen and Giovani Lo Celso.
- David de Gea
- Victor Lindelöf
- Harry Maguire
- Aaron Wan-Bissaka
- James Garner
- Daniel James
- Jesse Lingard
- Scott McTominay
- Mason Greenwood
- Marcus Rashford
Substitutes: Sergio Romero, Luke Shaw, Axel Tuanzebe, Brandon Williams, Ashley Young, Juan Mata, Andreas Pereira.
- Paulo Gazzaniga
- Toby Alderweireld
- Serge Aurier
- Davinson Sánchez
- Jan Vertonghen
- Dele Alli
- Moussa Sissoko
- Harry Winks
- Harry Kane
- Heung-Min Son
Substitutes: Juan Foyth, Danny Rose, Giovani Lo Celso, Eric Dier, Christian Eriksen, Tanguy Ndombele.
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