The Liverpool goalkeeper was injured by one of his own supporters.
The Spaniard saved Tammy Abraham's penalty in Istanbul this week as the Reds beat Chelsea in a shootout to lift the European Super Cup.
Immediately after saving it, the new Liverpool signing was swarmed by his team-mates but a fan wound up sliding into the former West Ham keeper after being able to find his way on to the pitch.
Jurgen Klopp confirmed on Friday that Adrian was a slight doubt for this afternoon's trip to Southampton with an ankle problem, calling it a 'crazy' incident.
Here's what Burley told ESPN: "They were on the pitch for a long time celebrating. It's a big deal long term, but I don't think it's that serious unless the fan had the big studs on! How the hell does this happen? It's crazy isn't it."
Klopp signed up Andy Lonergan as an emergency option earlier in the week and the former Leeds man made the bench against Chelsea, with Alisson already absent.
And if Adrian isn't fit this afternoon, the 35-year-old goalkeeper, who spent the second half of last season with Rochdale, could be in line for a quick debut.
Have something to tell us about this article?