Spurs realise that neither of the pair will come to White Hart Lane cheaply, and they are prepared to invest like never before to get them.
Spurs have already seen one bid for Lo Celso rejected, but they are set to make an improved offer to Betis in the coming weeks.
Tottenham are also hopeful of landing Ndombele, despite Lyon’s demands for big money.
If Tottenham could complete the double deal then Mauricio Pochettino’s side could really establish themselves among Europe’s elite.
Spurs’s squad was exposed for being short of depth at times last term, but Lo Celso's and Ndombele’s arrivals would give them one of the strongest midfield line-ups in Europe.
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