The 6ft 6in centre-back has been forced to sit out training with a minor niggle, the rigours of the season taking their toll on the player's body.
Vestergaard is one of several players who could miss out on the game, with Alex McCarthy, Matt Targett and Charlie Austin also having struggled in training, according to Hasenhuttl.
"Jannik Vestergaard has a little bit of a problem and didn’t train the last two days but today maybe he steps back in team training," the Austrian is quoted by the Daily Echo as saying on Thursday.
"Like in the last weeks also after intense games he had problems and needed longer for recovery, it’s a long season for a huge body and he’s struggling but we look to see if it is possible."
Since arriving at St Mary's in the summer from Bundesliga club Borussia Monchengladbach, Vestergaard had found himself in and out of the Saints' first-team picture before Hasenhuttl's appointment.
However, the 26-year-old Denmark international has become a crucial member of the manager's first team, as can be seen by his Transfermarkt season stats, and has been in great form in the club's quest against relegation.
With Southampton's game against Newcastle another key encounter in their battle against the drop, the Saints contingent will be desperate to find out whether Vestergaard can pass a late fitness test.
Here is how some fans reacted on Twitter:
4222 imo— tøby (@redmondszn) April 18, 2019
:(— kirsty (@ItsKirstyyy) April 18, 2019
Go away— Eli (@ELIELIELIELIEL_) April 18, 2019
4-2-2-2 it is then!— Aaron woodford (@AaronWoodford) April 18, 2019
Sons balling his eyes out— Charlie (@CharlieBones_) April 18, 2019
Was hoping he’d keep Rondon quiet— Charlie Hawkins (@charliehawk93) April 18, 2019
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