The Hammers, who are battling against relegation, travelled to Pride Park for a game against Derby County and twice came from behind to leave the East Midlands with a point in a 2-2 draw.
Marcus Olsson, returning from injury, saw his low cross turned home by Jayden Mitchell-Lawson to put the Rams ahead in the first half, and so it stayed until the break.
Jahmal Hector-Ingram replied for the Hammers in the second half before Josh Shonibare edged Derby ahead once again, only for Nathan Holland to make sure of a share of the points.
However, Tottenham Hotspur’s win at relegated Swansea City means that whether the Hammers retain their Premier League 2 Division 1 status is now out of their hands.
Up next for West Ham is their final game of the campaign, at the London Stadium against Everton, no easy task as the Toffees have been crowned league champions, and Manning admitted his players need picking up.
“It’s unfortunately out of our hands now,” he told the official West Ham website. “That was the challenge going into the game to keep it in our hands, in our control. It’s back on the lads now.
“It’s a great learning experience to go into the Everton game knowing it’s a must win game otherwise you’re relegated... there are some disappointed lads in there and rightly so. They need picking up and making sure they’re ready for Everton.”