Mauricio Pochettino’s Tottenham Hotspur will face Manchester City on Wednesday.
Kane is one of the best strikers in the world and is an important player for Tottenham, but the England international is injured at the moment.
The 25-year-old England international will miss Tottenham’s clash against Premier League rivals Manchester City this week.
Spurs will take on City away from home at the Etihad Stadium in the second leg of their Champions League quarter-final tie on Wednesday evening.
The North London outfit won the first leg of the tie 1-0 at White Hart Lane last week and will fancy their chances of progressing to the semi-finals of Europe’s premier club competition.
For Tottenham to advance further in the Champions League this season, they will have to do with Kane, and City midfielder De Bruyne - who joined the Citizens from German side Wolfsburg in the summer of 2015 for a transfer fee reported by BBC Sport to be worth £55 million - believes that Spurs should not be taken lightly.
De Bruyne told The Mirror: “Harry Kane is a wonderful striker, but it would be disrespectful to the other guys. They won against us without him when he went off last week and they have brilliant players.
“Earlier they won so many games without him before and they are still a very good team without him. Obviously he's a really good player, but it's not going to change anything.”