Mauricio Pochettino's side hold a one-goal advantage against their Manchester-based opponents and they travel to the Etihad on Wednesday night for the second-leg.
Heung-Min Son was the difference-maker last time out and he will be hoping to prove his worth when the two teams meet again, but Spurs will be without their star man Harry Kane.
France international Lloris, who has come under some stick in recent months, spoke about the tie and interestingly stated that his team will need 'nerve' to progress.
"It is the type of game all players want to play in," said Lloris, as quoted by the Daily Mail. "It is going to be about details – the same as the first leg. We need experience, nerve and spirit.
"The spirit has been fantastic the last few weeks but you can never feel comfortable. You always need to push your limits. That is going to be the case against City."
It is a tough ask for the North London club who will no doubt need to be at their utmost best if they are to qualify because City posses some serious attacking talent.
From the in-form Raheem Sterling to the magic of Kevin de Bruyne in the middle of the park and the ever-dangerous Sergio Aguero, it will be difficult to stop them all.
But Pochettino will be well aware that his team can be a threat themselves and a goal for his side at any time can potentially derail the hopes for the opposition team.