Goalkeeper Rui Patricio and midfielders Joao Moutinho, Ruben Neves and Diogo Jota are included in Fernando Santos's squad, with Cristiano Ronaldo also in the team for the first time since the 2018 World Cup.
Jota's inclusion is especially noteworthy because it is his first senior call-up, the 22-year-old having impressed for Wolves this season with six goals and four assists from 25 Premier League games, according to Transfermarkt.
In total, five players who ply their trade in the Premier League have been selected by the reigning European champions, with Manchester City playmaker Bernardo Silva completing the Selecao quintet travelling from England.
Wolves proudly announced the news on their Twitter account:
.@rpatricio1_, @JoaoMoutinho, @rubendsneves_ and @DiogoJota18 have all been called up by @selecaoportugal for their upcoming fixtures against Ukraine and Serbia.— Wolves (@Wolves) March 15, 2019
Congratulations to all and especially to @DiogoJota18 who earns his first senior call-up.
Some Wanderers faithful reacted on the social media platform with pride in their pack going on to represent the mighty nation:
Four players called up to the Portugal first team, class that is 100% deserved for Jota to be called up as well— Adam (@Adam_Virgo) March 15, 2019
Fantastic!! Fully deserved by all 4— Daniel Box /\_/\ (@DanielBox87) March 15, 2019
Marvelous news, fully deserved , proud & pleased for the lads .— Alan Leese. (@_AlanLeese) March 15, 2019
Diogo listed immediately under ronaldo!!!— John holding (@Glastowolf) March 15, 2019
Fantastic. They deserve it.— M. J.50 years a Wolf (@MJ96838192) March 15, 2019
Well done Diogo, thoroughly deserved lad— Danny Rosamond (@DannyRosamond) March 15, 2019
Portugal triumphed over France at Euro 2016 but were knocked out of the 2018 World Cup in the round of 16 at the hands of Uruguay.