Wilder will be up against his third different Wednesday boss in four games when he takes his United side to Hillsborough on Monday, after the appointment of Steve Bruce in January.
Speaking via the BBC on Thursday, Bruce acknowledged the magnitude of this particular fixture and what it means to supporters on either side of the city.
"It's a fantastic occasion," said the Sheffield United manager. "I know there's been a couple of different opinions from the opposition managers over the last couple of years.
"I think Carlos said it's just a game, which I didn't get, and the other guy said he's played in bigger, which I didn't get even more.
"But Steve's hit the nail on the head. Being the man that he is. Being brought up in the north east, and being involved in that. Being involved in Manchester derbies. Being involved in a so-called derby, a Liverpool/Manchester United derby.
"So he gets it, I get it, our supporters get it, their supporters get it, the players get it and it's great to be involved in."
Both teams go in to the game having lost just one of their last 12 in the Championship, although Sheffield United have won two more of those and drawn two fewer.
Depending on other results, the Blades may have a chance to go top of the league, while Sheffield Wednesday will be looking to close the gap on those standing in the way of the top six.
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