Southampton starting line-up: McCarthy; Valery, Bednarek, Vestergaard, Yoshida, Targett; Romeu, Lemina; Armstrong, Redmond, Ings.
Southampton substitutes: Gunn, Ramsay, Stephens, Ward-Prowse, Elyounoussi, Long, Austin.
West Ham United starting line-up: Fabiański; Antonio, Diop, Ogbonna, Cresswell; Rice, Obiang; Snodgrass, Diangana, Anderson; Pérez.
West Ham United substitutes: Adrian, Masuaku, Coventry, Noble, Silva, Carroll.
Southampton head into the game having beaten Huddersfield Town 3-1 on Saturday afternoon, and will be looking to make it three wins in a row under new boss Ralph Hasenhuttl.
Alex McCarthy continues in goal, with a back five of Yan Valery, Jan Bednarek, Jannik Vestergaard, Maya Yoshida and Matt Targett in front of him.
Mario Lemina returns in place of the suspended Pierre-Emile Hojbjerg, joining Oriol Romeu in midfield, behind Stuart Armstrong, Danny Ings and Nathan Redmond.
Mohamed Elyounoussi joins Angus Gunn, Kayne Ramsay, Jack Stephens, James Ward-Prowse, Shane Long and Charlie Austin.
Meanwhile, West Ham are looking to bounce back having lost 2-0 at home to Watford on Saturday afternoon, and they continue with Lukasz Fabianski in goal.
Michail Antonio, Issa Diop, Angelo Ogbonna and Aaron Cresswell are across the back four, with Declan Rice and Pedro Obiang in the heart of midfield.
Robert Snodgrass and Grady Diangana line up out wide, with Felipe Anderson operating behind lone striker Lucas Perez; Javier Hernandez hasn't been passed fit.
Manuel Pellegrini has only been able to name six substitutes tonight; Adrian San Miguel, Arthur Masuaku, Conor Coventry, Mark Noble, Xande Silva and Andy Carroll.
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