Manuel Pellegrini has a plethora of injuries to contend with, but will still be able to name a strong side against the Cottagers.
Lucas Perez started the Hammers' last game against Crystal Palace, but was substituted at half-time in place of Andy Carroll, and the 6ft 4in target man might just get the nod to start the game at Craven Cottage.
Pellegrini might also opt to bring in Aaron Cresswell in place of Arthur Masuaku for Saturday's game.
The 28-year-old has not played since picking up a hamstring injury against Newcastle at the start of the month, but he was on the bench against Palace.
Masuaku is a defensive liability, so the West Ham boss will surely be tempted to bring in the more solid Cresswell.
Other than that, it should be pretty munch the same as last weekend.
Fabianski will keep his place between the sticks, behind a back four of Pablo Zabaleta, Issa Diop, Fabian Balbuena and Cresswell.
Pellegrini could of course choose to play Michail Antonio instead of Zabaleta at right-back, but the Argentine's fine performance against Palace should ensure that he keeps his place.
Mark Noble and Declan Rice should start in the middle of the park, flanked by red-hot duo Felipe Anderson and Robert Snodgrass.
Javier Hernandez will likely keep his place up front in support of either Andy Carroll or Lucas Perez.
The big Geordie seems to be back to somewhere near his best physically, however, so he might just get the nod over the Spaniard.