Alli and Eriksen are both still making their way back to full fitness, after injury.
The Spurs pair were required to start in midweek, as Pochettino’s side squeezed past PSV Eindhoven in the Champions League.
And Pochettino has hinted that Alli and Eriksen may have to drop down to the substitutes’ bench at Selhurst Park this weekend.
“We will see on Saturday, it was a tough game against PSV in the Champions League,” Pochettino said, when asked if Alli and Eriksen will be able to start for Tottenham this weekend.
“Then they are going to move to the national team I think. It will be tough to play two games. That is why we need to care and send them really fresh. That is why we are thinking if they are going to play or not against Palace.”
If Alli and Eriksen are missing then Tottenham’s task of beating Palace will only be made harder.
Spurs are likely to start Erik Lamela and Lucas Moura as their main creative outlets, should the attacking midfielder pair be out.
Tottenham go into their match against Palace looking to protect their place in the top four.
Spurs have kept pace with most of the league leaders so far, after making an impressive start to the campaign in the Premier League.