Jurgen Klopp's team went down 2-0 to Red Star Belgrade on Tuesday evening and they need to reply in a positive fashion with a convincing win on Sunday.
So bad was Liverpool's result and performance on Tuesday night, Jurgen Klopp and his team know that a positive response is vital this weekend. With no offence intended to Fulham, the Reds could not have hoped for a more suitable fixture on the back of their defeat in Belgrade.
Fulham are bottom of the Premier League and set themselves up in such an expansive fashion that this Liverpool team could be licking their lips at the thoughts of facing them on Sunday.
Slavisa Jokanovic, the Fulham boss, is the odds-on favourite to be the next Premier League manager to lose his job and a heavy defeat at Anfield could be the final straw for the Fulham board.
The Cottagers have conceded 29 goals in 11 league games, an average of almost three goals per game. While this Reds side may not be the attacking force they were at stages last season, they are sure to be confident of bagging three, four or more on Sunday.
Jokanovic needs to counteract Liverpool's approach with some tactical variation if he really wants to keep his job. Stars such as Ryan Sessegnon will have to sacrifice their own attacking exploits in the name of defensive solidity on Sunday.
Liverpool's front three have not been firing on all cylinders and Klopp can make one of two choices for Sunday's game. Does he put them out together against the weakest defence in the league with the aim of using this game to help them 'click' again? Or does he afford Mohamed Salah, Roberto Firmino and Sadio Mane some time apart?
Klopp needs to revisit the 4-2-3-1 shape that worked well against Cardiff City. This formation was Klopp's favoured team setup during his glory years with Dortmund and he has the required personnel to make it work now at Anfield, too.
With the international break coming up, Klopp is bound to go full throttle at Fulham so not many players are likely to be rested.
At the back, Dejan Lovren will most likely come in and partner Virgil van Dijk in the centre, with Joe Gomez moving out to right-back in place of Trent Alexander-Arnold.
James Milner impressed in the early weeks of the season but his performances of late have been less than what we've come to expect from the veteran midfielder. As a result, Gini Wijnaldum should partner Fabinho at the base of the midfield with a trio of Xherdan Shaqiri, Firmino and Mane supporting the pacy frontman, Salah.
The Reds simply have to win to stay within touching distance of Manchester City. Such is the level of Manchester City's consistency, teams know they have to win over 80% of their own league games to even hang onto the coattails of Pep Guardiola's men.