West Ham United travel to Leicester City on Saturday off the back of consecutive defeats and with a torrid injury list.
West Ham looked to have turned their season around after a dreadful start to the season following the victories over Everton and Manchester United and a fine 0-0 draw with Chelsea.
But back-to-back defeats away to Brighton and at home to bitter rivals Tottenham has proved a setback.
With no fewer than seven first team players out, many for the season including new summer signings Carlos Sanchez and Andriy Yarmolenko, things are starting to unravel for Pellegrini as he finds his squad simply does not have the necessary quality in depth.
Leicester away suddenly represents a daunting proposition and Pellegrini could be forced to reshape his team to try and turn the corner again.
It is not yet known whether Pedro Obiang will be fit for the trip to the King Power but Pellegrini looks set to make three changes from the side which started against Spurs last time out.
Obiang in for Snodgrass
It is a massive blow to lose creative Ukrainian Yarmolenko and while Robert Snodgrass probably deserves to keep the shirt for his effort alone he simply does not offer enough pace or creativity at Premier League level to move across and fill in for either Snodgrass or Yarmolenko. Obiang, if fit, will come in to the centre to replace Snodgrass.
Masuaku in for Noble
Not a straight swap but Masuaku simply cannot be trusted at left back as his defensive capabilities are not sufficient for Premier League level. What Masuaku does bring is pure pace and trickery and he should come into the side on the left with Felipe Anderson moving into a central role in place of Mark Noble, who has been desperately poor in the last two games.
Antonio in for Yarmolenko
Antonio has been struggling for game time and form and simply hasn't taken his chances when they have come along under Pellegrini. He is very much a player that needs to feel loved and wanted but he also hasn't been putting in the same level of effort which so endeared him to Hammers fans. Now he is likely to have a long run in the side with Yarmolenko's injury and he must step up.