The 37-year-old former Tottenham forward has also backed both Spurs and Liverpool in the Premier League match.
Berbatov told Betfair: Liverpool have got off to a great start, winning every game and playing good football.
“The team looks very balanced and it's going to be very tough for Tottenham, despite home advantage.
“I expect both teams to score as they usually do in this fixture, but I'll have to edge towards Liverpool to win it.”
While predicting Liverpool to win against Tottenham, Owen wrote on Betvictor.com: “Whether Spurs can stop a rampaging Liverpool forward line looks unlikely, however, and five wins on the bounce for Jurgen Klopp’s side beckons.”
Both Tottenham and Liverpool are attack-minded teams, and Saturday afternoon’s match does promise to be a hugely exciting one.
While Spurs will have home advantage, the Reds have one of the best and most potent attacking unit in Europe.
Mohamed Salah will be a key player for Liverpool, and the Egypt international winger could well score one or two goals for the Merseyside outfit.
Harry Kane will have to step up his game. The England international has not been in great form so far this season, and the striker will have to play an influential role against Liverpool at Wembley on Saturday.