Harry Kane ran the Croatia international ragged, twice getting the better of him to set Tottenham up 2-0 within the opening 15 minutes, eventually prompting Reds manager Jurgen Klopp to haul him off.
The players meet again on Wednesday when Croatia and England clash and, with a place in the World Cup final at stake, there is no better time and chance for Lovren to finally redeem himself.
Kane is every defender's nightmare and, with six goals to his name at the tournament, the Englishman is raring to go as the Three Lions look to win their second ever World Cup.
Lovren has improved greatly since that October debacle, playing a huge role in Liverpool's incredible Champions League campaign and Croatia's astonishing run thus far.
But he is yet to fully convince and win the trust of everyone, and is still susceptible to occasional errors, highlighted by his stray pass that allowed Russia a chance to go clear on goal in the closing minutes of the quarter-final.
Wednesday's game is Lovren's biggest on the international stage thus far, and it is perhaps his toughest test after the Champions League final, which he aced.
Coming out on top against Kane, and successfully shutting out or limiting the damage from the Tottenham star and England, to send Croatia to their first ever World Cup final would no doubt earn Lovren lots of respect and accolades, and the Liverpool man will surely be looking forward to grabbing a once-in-a-lifetime opportunity with both hands.