Tottenham striker scored twice for England including dramatic late winner.
His last gasp injury time header sealed a 2-1 victory for the Three Lions, following up his first half strike.
Kane's late goal prompted former Spurs striker Gary Lineker to swear in celebration.
Lineker posted via Twitter: "Get in you f***ing beauty. Harry the great."
Kane could not have asked for a more perfect start on an individual level, although England got lucky.
The Spurs striker scored two opportunistic goals from set pieces.
England's opener was cancelled out by a soft penalty conceded by Kyle Walker and they only improved in the second half when Ruben Loftus Cheek and Marcus Rashford came on and helped change the game.
Up next for England are Panama, who lost their opener 3-0 to Belgium.