There is little pressure on Tottenham to beat the Cypriot champions after Pochettino's side already topped Group H in the Champions League ahead of Real Madrid and Borussia Dortmund.
Consequently, the Argentine manager is expected to name a much-changed first XI from the side that drew 1-1 at Watford on Saturday and several big-name Spurs men should drop to the bench.
Eriksen is one of a host of Pochettino's players to come in for criticism in recent weeks, with the Danish playmaker not looking himself since inspiring his country to a World Cup playoff win over the Republic of Ireland last month.
And Nicholas believes that his heroics on international duty have taken their toll on the former Ajax man, suggesting that Pochettino is growing frustrated with his recent performances.
He told Sky Sports: "Well, I'm going for Spurs to get back on the winning trail. APOEL were awkward at home before Spurs put their foot on the gas impressively.
"I suspect Mauricio Pochettino is getting a bit frustrated with a few players and I think Christian Eriksen will be rested. I think the double-header with the Republic of Ireland took a lot out of Eriksen, physically and mentally, so he could do with a checkout."