West Ham are languishing in the relegation zone ahead of the trip to Watford after just two wins from their opening 11 games.
That cost Slaven Bilic his job and the Croatian was quickly replaced with David Moyes taking over last week.
The Hammers face three crucial fixtures against the Hornets, Leicester City and Everton before a run of daunting matches against Manchester City, Chelsea and two games against Arsenal in a week in the league and Carabao Cup.
There has been much speculation about which players Moyes will favour given West Ham's predicament.
Here is the predicted line-up the Scotsman will select for his first game based on his football ethos, injuries and form, with three changes to the side which lost 4-1 to Liverpool last time out.
Andy Carroll in for Javier Hernandez
Andy Carroll is deemed by many fans and pundits as crucial to West Ham's chances of survival. But some feel his presence in the starting line-up dictates that the Hammers play a certain way, which often makes them easy to defend against. In this instance Moyes has his hand forced with Javier Hernandez reportedly out of the game after picking up a hamstring injury playing for Mexico during the international break.
Diafra Sakho in for Andre Ayew
Moyes has publicly stated the slate will be wiped clean for all players after his arrival. And that is great news for Diafra Sakho who will be full of confidence after scoring for Senegal to send them to the World Cup. Sakho is the best all round striker at the club with pace, mobility, aerial prowess and finishing stats up there with the best. His injury record gives Carroll a run for his money but he is fit and should partner the Geordie up front at Vicarage Road. Ayew is unlucky to miss out after a decent run of form of late but Sakho has more pace and can help bully and stretch the Hornets defence.
Pablo Zabaleta in for Edimilson Fernandes
After missing out against Liverpool due to suspension, experienced fullback Pablo Zabaleta should come back into the side to replace Edimilson Fernandes who was badly exposed by Liverpool albeit playing out of position on the right side of a back five. Zabaleta's own form has been up and down this season and he has not always covered himself in glory but his Moyes will likely be keen to lean on the Argentine's vast experience.
50/50: Declan Rice in for Winston Reid
Young Declan Rice could replace key defender Winston Reid in the side IF the New Zealander is not in condition to start the game. Reid has been away playing in World Cup qualifying action for the Kiwis against Peru and will not arrive back in London until Saturday - less than 24 hours before the game against Watford. If fit Reid might make the match but it could be that Rice replaces him with the more experienced player on the bench if required.