Mauricio Pochettino returns to his former club in this televised festive fixture on Wednesday evening.
Southampton have not been firing on all cylinders this season, but they still find themselves sitting pretty in seventh and there have been signs in recent weeks that they are moving through the gears.
The 3-1 win at Bournemouth last time out stretched their unbeaten run to three matches and, with no Europa League football to distract them in the New Year, Claude Puel's side could yet launch an assault on the top six.
Tottenham are safely within those European spots for the time being but have work to do if they are to earn another crack at the Champions League. The 2-1 win over Burnley before Christmas kept them within touching distance, with Watford and Chelsea to follow for Spurs in the coming days.
Southampton's Virgil van Dijk reacts
The Key Battle - Virgil van Dijk vs Harry Kane
There are rumours surrounding the future of both of Southampton's key centre-backs, with speculation that Van Dijk and Jose Fonte could both be on their way out of St Mary's in January.
The Dutchman has been particularly impressive this term, and will have to be on his game to stop Kane finding the net at St Mary's.
Tottenham's Harry Kane
A Steven Davis double inspired Saints to an excellent win at White Hart Lane in May's encounter between these two sides.
Overall, Tottenham have the edge with 51 wins in this fixture to Southampton's 37.
Tottenham Hotspur's Kyle Walker in action with Southampton's Steven Davis
Recent league form – most recent last:
Southampton - DWLWDW
Tottenham - WLWLWW
Who’s the ref?
Fresh from overseeing the Merseyside derby before Christmas, Mike Dean will be in charge on the south coast.
Dean has taken control of 15 matches this season, producing 67 yellow cards and three reds in the process.
Everton's Idrissa Gueye is shown a yellow card by referee Mike Dean after fouling Liverpool's Sadio Mane
What time is kick off?
The match starts at 7.45pm.
Where can I watch it?
Southampton v Tottenham is live on Sky Sports 1, with coverage beginning at 7.30pm.
Southampton - 15/8
Draw - 9/4
Tottenham - 6/4
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