The Baggies entertain Jose Mourinho's men at The Hawthorns on Saturday evening.
The Baggies are fresh off a 3-1 victory over Swansea City in midweek, with Salomon Rondon scoring his first hat-trick since his arrival in England, with three goals coming in thirteen second half minutes.
West Brom's Salomon Rondon celebrates scoring their third goal and completing his hat-trick
The Venezuelan will be keen the emulate last season's result, when his only goal of the game back in March, was enough to give the hosts their first win over United since a League Cup victory in 2003.
Tony Pulis' men have won their last three games at home and have lost just twice at The Hawthorns this term in a more attacking 4-2-3-1 approach, as they seek to make it in four-in-a-row this weekend against The Red Devils.
Jose Mourinho's men roll up to the West Midlands, aiming to pick up a third successive league win on the bounce for the first time since August.
United's 2-1 defeat of Crystal Palace at Selhurst Park on Wednesday, saw Zlatan Ibrahimovic net his ninth of the campaign so far, as the Swede's chemistry with Paul Pogba continues to bare fruit.
Manchester United's Zlatan Ibrahimovic scores their second goal
In the head to head record between the sides, Mourinho's men have notched 13 wins of 20 Premier League clashes.
Perhaps their most dramatic was in a largely dead-rubber meeting on the final day of the 2012/13 campaign, where a Romelu Lukaku hat-trick earned a point a in 5-5 classic - The Baggies coming from 5-2 down with ten minutes to play to snatch a point.
Romelu Lukaku (L) celebrates scoring the second goal for West Brom
Defender Craig Dawson returns from suspension having missed the game against The Swans on Wednesday night. Former United man Jonny Evans is also set to make his comeback from a calf problem.
The duo of Boaz Myhill and Saido Berahino are continued absentees, with ankle and fitness concerns.
Here is how West Brom could lineup:
For the visitors, defender Antonio Valencia returns from suspension and Chris Smalling should be passed fit to take to his place after a broken toe. Eric Bailly and Luke Shaw are both absent.
Henrikh Mkhitaryan is set to return on Boxing Day from an ankle injury.
Here is how Manchester United could lineup:
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