Diafra Sakho and Abel Hernandez are among those who are sidelined for Saturday's Premier League clash at the London Stadium.
At the start of the season, not many would have expected West Ham versus Hull to be a crunch clash at the bottom of the Premier League with Christmas approaching.
Admittedly, the Tigers were expected to struggle, but the Hammers have been performing hugely beneath expectations after their excellent season last time around and go into the weekend just four points above the bottom three.
West Ham United manager Slaven Bilic
This week has shown signs of improvement, however.
Three points on Saturday would cap a successful six days for Slaven Bilic's side, who picked up a point at Anfield last Sunday before recording their first league win since October against Burnley in midweek.
Hammers supporters will be hoping this represents a corner being turned in their season and will be expecting their side to pull away from trouble in the second half of the season as they get more acquainted with their new home.
West Ham United's Gokhan Tore remains sidelined
If they are to win this weekend, they will have to do so without a number of first team regulars. Diafra Sakho, Sam Byram, James Collins, Simone Zaza, Gokhan Tore and Reece Oxford - who today signed a new contract - are all out for the hosts.
Visitors Hull have their own injury problems, with Abel Hernandez, Allan McGregor, Alex Bruce, Moses Odubajo, Will Keane and Greg Luer all sidelined for Mike Phelan's side.
Hull City's Abel Hernandez sustains an injury
The Tigers are able to welcome back Dieumerci Mbokani for their first ever trip to the London Stadium, as the forward has now served his three-match suspension after seeing red against Newcastle in the EFL Cup.
A 3-0 defeat at Tottenham on Wednesday left Hull second bottom and with comfortably the worst goal difference (-21) in the division, with no team having conceded more than City's 35 goals so far.
Tottenham's Victor Wanyama in action with Hull City's Harry Maguire
It has been a difficult winter for Phelan to date, as his side have won just once in 14 Premier League matches; they will have to pick up going into the New Year if they are to avoid an instant return to the second tier.
Who will come out on top as West Ham take on Hull? Leave your predictions below.
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