The south coast rivals go head-to-head at the Vitality Stadium on Sunday lunchtime - here is all you need to know ahead of the clash.
On the south coast, it is still Southampton's derby with Portsmouth that stirs up the most emotion. This Sunday, however, they travel to the home of near neighbours Bournemouth meeting them as equals, with both teams sat on 21 points after 16 matches.
The Cherries rose to the dizzying heights of eighth after defeating Leicester in midweek - the highest league position the club has ever had - and, though they dropped a couple of places after Wednesday's matches, Eddie Howe will be more than satisfied with his side so far.
Southampton claimed a point at Stoke in midweek to leapfrog their neighbours ahead of Sunday's clash, but goals remain a problem for Claude Puel's side. They have scored just 14 so far - less than a goal a game - which makes the absence of Charlie Austin an even bigger blow.
Southampton's Sofiane Boufal celebrates scoring their first goal against Middlesbrough
The Key Battle - Jack Wilshere vs Oriol Romeu
The Arsenal loanee continues to impress for the Cherries as he makes the most of an injury-free spell, and now needs to start adding goals to his game to further benefit his side.
Romeu has been a consistently solid performer in the Saints midfield this season and will be looking to deny Wilshere the space he craves between the lines.
Bournemouth's Jack Wilshere in action with Liverpool's Jordan Henderson
Goals from Steve Cook and Benik Afobe secured a famous victory for Bournemouth in March's meeting between the two clubs at the Vitality Stadium.
Overall, Saints have the edge in this fixture, with 10 wins to Bournemouth's seven.
Bournemouth's Benik Afobe in action
Recent league form – most recent last:
Bournemouth - LWLWLW
Southampton - LDWLWD
Who’s the ref?
Mark Clattenburg will be in charge on the south coast.
The 41-year-old has shown 64 yellow cards in his 17 games so far this season, and showed the latest of his three red cards to Everton's Phil Jagielka in their 2-1 win over Arsenal on Tuesday.
Southampton manager Claude Puel reacts
What time is kick off?
The match starts at 1.30pm.
Where can I watch it?
Bournemouth v Southampton is live on Sky Sports 1 as the first part of the Super Sunday double header, with coverage starting at 12.30pm.
Bournemouth - 19/10
Draw - 9/4
Southampton - 7/5
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