Ronald Koeman returns to his former club for the first time since leaving in the summer - here is how you can see how he fares.
Everton manager Ronald Koeman
Despite leading Southampton to seventh and sixth placed finishes during his two seasons on the south coast, Ronald Koeman may still receive a frosty reception as he returns to St Mary's with Everton for the first time.
Saints have recovered from the loss of the Dutchman and look in solid shape under Claude Puel, though they are without a win in their last four Premier League games and were defeated by Sparta Prague in the Europa League in midweek.
Koeman's Everton side have also been in indifferent form of late. They were held at home by bottom club Swansea last weekend and have won just once in their past seven league games.
The Key Battle - Oriol Romeu vs Ross Barkley
The Spanish midfielder has impressed for Saints this season, protecting the back four well and using the ball effectively.
Barkley showed signs of improvement against Swansea last time out but is yet to truly spark into life in 2016/17. He will be looking to have a match-winning impact for his side on the south coast.
Southampton's Oriol Romeu in action with Leicester City's Jamie Vardy
The spoils were shared the last time these two sides met, with Sadio Mane's equaliser securing a point for Saints at Goodison Park after Ramiro Funes Mori's opener.
The most recent battle at St Mary's saw Everton cruise to a 3-0 victory last August, with a Romelu Lukaku brace helping the Toffees on their way to their first win at Southampton since 2002.
Everton's Romelu Lukaku celebrates scoring their first goal with team mates
Recent league form – most recent last:
Southampton - DWDLLD
Everton - DDLWLD
Who’s the ref?
Craig Pawson will have the whistle at St Mary's.
The South Yorkshire-based official oversaw the clash between these two sides at Goodison Park last season, and has shown 41 yellow cards and one red in his 11 games during this campaign to date.
Referee Craig Pawson (L)
What time is kick off?
The match starts at 4.30pm.
Where can I watch it?
Sky Sports 1 are showing this one. It is the final part of Sunday's Premier League triple header, and build-up will begin at around 4.15pm after Arsenal's clash with Bournemouth.
Southampton - 11/10
Draw - 23/10
Everton - 5/2