Kompany could miss crucial games against the likes of Arsenal, Chelsea and Liverpool during his spell on the sidelines.
Manchester City manager Pep Guardiola has confirmed that captain Vincent Kompany is sidelined for four to six weeks with a knee ligament injury, the club's official website reports.
It's the latest in a long line of injuries for the Belgian defender but it comes when City are approaching a very busy period in their season.
Not only is it a busy period of the season, but there are many huge games where City will be without their captain.
If it's a four week lay-off, Kompany could be back in time for the Boxing Day clash with Hull City at the KCOM Stadium.
Pep Guardiola told reporters at his press conference, as reported by the club's official website: “It is a ligament problem. He will be four to six weeks out."
Manchester City manager Pep Guardiola during the press conference
The games that Kompany look certain to miss include crucial home clashes in the Premier League against Chelsea and Arsenal. Other games he will miss will be tomorrow lunchtime's trip to Burnley, Leicester City, and a home clash with Watford.
He will also miss their dead rubber Champions League group game with Celtic at the Etihad Stadium.
If his injury lay-off is closer to six weeks then another big game sticks out as he would likely miss the trip to Anfield to take on Liverpool - in what could be another huge game in the title race, and then the return fixture against Burnley a couple of days later, as well as the trip to Humberside over Christmas.
The first league game he would likely return for is the trip to Everton on January 15 - though he could be available for the FA Cup third round tie the week before.
Manchester City's Vincent Kompany walks off the pitch after going down with an injury