Pep Guardiola's side make the short trip to Turf Moor on Saturday lunchtime - here is all you need to know.
Fresh from a 4-0 thumping at the hands of West Brom on Monday evening, Burnley face the unenviable task of trying to bounce back against star-studded near neighbours Manchester City this weekend.
The visitors will go top - for a few hours at least - with a win at Turf Moor in a match which rounds off a tricky week of away fixtures for City.
Having survived unscathed from trips to Crystal Palace and Borussia Monchengladbach, Pep Guardiola will hope his side can continue their strong form against Sean Dyche's men.
The Key Battle - Michael Keane vs Sergio Aguero
Keane's impressive performances at the heart of Burnley's defence this season have seen him named in both of Gareth Southgate's England squads, and he has a chance to show he can cut it against world class performers when Aguero comes to town on Saturday.
Manchester City's Sergio Aguero in action
The City frontman has scored 14 goals in just 17 apperances across all competitions this season and will be ready to profit if Burnley's defensive horror show from the Hawthorns continues into this match.
The Clarets claimed a famous win in the last clash between these two sides, with George Boyd's second half strike securing a 1-0 win for the hosts.
Overall, Manchester City have won this fixture 40 times, Burnley have earned 30 victories and there have been 24 draws.
Burnley's George Boyd shoots at goal
Recent league form – most recent last:
Burnley - LLWDWL
Manchester City - LDDWDW
Who’s the ref?
Andre Marriner will be in charge on Saturday lunchtime.
Burnley fans looking for good omens will be pleased to note that the 45-year-old oversaw their aforementioned 1-0 win in March 2015.
What time is kick off?
The Lancashire battle begins at 12.30pm.
Manchester City's Kevin De Bruyne
Where can I watch it?
BT Sport 1 are showing this one, with coverage beginning at 12pm.
Burnley - 9/1
Draw - 9/2
Manchester City - 2/7