The Tigers are struggling for goals and have been dealt a double injury blow.
He is the Tigers' main goalscoring threat and was forced off just nine minutes into the clash with the Saints.
Fellow forward Will Keane was also hauled off due to a more serious knee injury with Tigers boss Mike Phelan unsure about the scale of the issue so. With those two injured, and Adama Diomande not figuring on Sunday, the only striking option was the former Norwich forward Dieumerci Mbokani.
With that in mind, it looks like Hull will have to delve into the transfer market in January to bolster their options up front. So who should they target?
The Senegalese forward had an electric start to his career in the Premier League by equalling Mick Quinn's record of scoring in his first six starts in the Premier League. He looked so perfectly suited to the English game combining pace with strength, good aerial ability and finishing prowess.
He continued his fine form throughout his debut season and ended the campaign with 12 goals in 26 appearances in all competitions, an impressive strike rate of nearly one in every two games. However, last season, he was very much in and out of the starting line up, spending three months out with a thigh injury.
Moves to Sunderland and West Brom collapsed during the summer and the 26-year-old in currently frozen out at the Olympic Stadium. A move to Hull would seemingly suit all parties.
Another Senegalese striker, the former Lokomotiv Moscow man has had a miserable time in English football since completing a £13.5 million to Everton in January. He was scoring for fun in Russia and that convinced former Toffees boss Roberto Martinez to take a punt on the 26-year-old.
However, he has flopped badly and after just five appearances without scoring, Niasse was told by new manager Ronald Koeman that he was not part of his plans and should leave the club. He was demoted to the reserve squad, had his squad number taken away and was told to move his personal locker.
Niasse recently gave an interview to The Guardian saying he does not deserve that treatment. However, his future on Merseyside looks incredibly bleak so a switch to Hull may reinvigorate the obviously determined striker and give him the chance to perform in the Premier League.
The once-capped England man was a key player in Middlesbrough's promotion to the Premier League last season. But with boss Aitor Karanka favouring the more robust and physical compatriot Alvaro Negredo up front, opportunities for the 31-year-old former Leicester City forward have been rare, with just four substitute appearances made in the Premier League.
Nugent, would bring a directness and energy to Hull's front line which is what they definitely need in order to survive relegation at the first attempt, with their other options being more about technique and height.
A loan move would potentially be the most obvious with this deal, but it is one that Mike Phelan may wish to pursue in January.
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