On the back of last weekend's 2-1 derby defeat to Manchester City and Thursday's Europa League loss at Feyenoord, Manchester United were looking to get their season back on track with a win over Watford.
Watford took the lead in the first half through Etienne Capoue, but Marcus Rashford equalised on the hour mark, giving United hope of victory.
But the introduction of Juan Zuniga put paid to that ambition, as he scored within 60 seconds of entering the fray. Troy Deeney put the icing on the Watford cake with a converted penalty in added time.
Here are three players who did not perform to the best of their ability at Vicarage Road.
The world-record signing got his second stint with United off to a decent start in the win over Southampton, but since then it has not gone the Frenchman's way.
Pogba went missing during last weekend's derby defeat and he fared no better against Watford.
Though he showed the odd sign of his skills (he hit one 25-yard shot that hit the crossbar), he found himself far too deep throughout and failed to get a stranglehold on the match.
He made only one touch in the opponent's area, with only two other touches anywhere remotely near to it.
If he is to show that he is worthy of his £89 million value, he will need to be given the chance to play much higher up where he can show off his attacking talents. For now, Pogba is just treading water.
The United and England captain is the player that fans love to hate. Despite holding such prominent roles for club and country, he is consistently lambasted by fans for a perceived lack of speed and tempo to his play, often being deemed to be the blockage that slows down United's attacking play.
Rooney did not have one of his better games today. Whereas against Hull he came under fire but still managed to make a key contribution with the cross for Marcus Rashford's winner, Rooney was unable to fashion any vital passages of play as his team was convincingly beaten.
Rooney did not pose any threat to the Hornets. If he carries on performing like this, Jose Mourinho may find himself in a position where he has to drop his skipper.
Smalling missed the first few games of the season, but the combination of Eric Bailly and Daley Blind performed well enough that United did not suffer due to missing their first-choice defender.
Now fit, Smalling was selected ahead of Blind after a poor showing from the Dutchman during the derby, but he did not have one of his better games.
The most memorable (for all the wrong reasons) aspect of his performance was the early incident with David De Gea, where a breakdown in communication meant that the two men collided, leaving Odion Ighalo with an open goal. Fortunately for United, the striker somehow missed the target.
The 26-year-old had a tough time dealing with the strength of Troy Deeney throughout, and while his plight was no worse than that of his teammates, he will have to perform better if he is to stay in the starting XI.
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