Origi limped off with a hamstring injury in the Boxing Day win over Leicester City and Jurgen Klopp updated the media on the condition of his squad.
It represents something of a blow for the Reds given the shortage of striking options as Danny Ings is out for the season with an ACL injury, while Daniel Sturridge's injury problems are well documented - though it is thought he is nearing a return to action.
The injury comes at a key time in Liverpool's season with difficult Premier League fixtures against West Ham United, Arsenal and Manchester United as well as the first leg of the League Cup semi-final against Stoke City, and the Reds' FA Cup campaign gets underway when they travel to face Exeter City next week.
It's a shame that Origi is sidelined because he has shown a lot of promise of late - having scored a hat-trick in the League Cup win over Southampton as well as an equalising goal against West Bromwich Albion.
He has improved a great deal from Jurgen Klopp's first games in charge when he was asked to lead the line as resources were scarce in the final third.
Christian Benteke is currently the club's only available recognised forward, though Roberto Firmino can also play in the role.
However, at his pre-match press conference today, Klopp told reporters that Sturridge could feature in this weekend's trip to West Ham United after being recently sidelined with a hamstring injury.
The full extent of Jordan Henderson's injury is unknown, the Liverpool Echo reported in their live blog, after he limped off in the win over Sunderland but it is a recurrence of his heel problem, while James Milner remains sidelined with a calf problem. Joe Allen missed the trip to Wearside through illness.