Tottenham Hotspur starting XI: Lloris; Aurier, Sanchez, Dier, Reguilon; Hojbjerg, Sissoko; Lucas, Ndombele, Son; Kane.
Tottenham Hotspur substitutes: Hart, Alderweireld, Davies, Tanganga, Winks, White, Alli, Bergwijn, Vinicius.
Brentford starting XI: Raya; Dalsgaard, Pinnock, Sorensen, Henry; Janelt, Dasilva, Jensen; Mbeumo, Canos, Toney.
Brentford substitutes: Daniels, Marcondes, Forss, Ghoddos, Fosu, Roerslev, Stevens, Gilbert, Haygarth.
Tottenham go with Hugo Lloris in goal, whilst Serge Aurier and Sergio Reguilon return in the full back positions.
Davinson Sanchez comes into the heart of defence with Eric Dier, whilst Moussa Sissoko is reunited with Pierre-Emile Hojbjerg in midfield.
Tanguy Ndombele will be given more license to get forward, supporting the front three of Lucas Moura, Son Heung-min and Harry Kane.
That means Dele Alli is only on the bench, joining Joe Hart, Toby Alderweireld, Ben Davies, Japhet Tanganga, Harry Winks, Harvey White, Steven Bergwijn and Carlos Vinicius.
Brentford have David Raya between the sticks, behind a back four of Henrik Dalsgaard, Ethan Pinnock, Mads Sorensen and Rico Henry.
Vitaly Janelt is joined in midfield by Mathias Jensen and ex-Arsenal talent Josh Dasilva, with Bryan Mbeumo and Sergi Canos supporting Ivan Toney up top.
Marcus Forss and Emiliano Marcondes are on the bench, joining Luke Daniels, Saman Ghoddos, Tariqe Fosu, Mads Roerslev, Fin Stevens, Alex Gilbert and Max Haygarth.
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