Five men who have been good for Claude Puel's Saints.
Barcelona could be about to battle it out with Southampton for a centre-half, according to reports in Spain.
Southampton defender Virgil van Dijk has been targeted by the likes of Liverpool and Manchester United.
Southampton have lost Jose Fonte and Virgil van Dijk to West Ham United and injury respectively.
West Ham have snapped up Jose Fonte from Southampton - prompting a reaction from Virgil van Dijk on Twitter.
What would a combined XI consisting of the current Southampton side and the one that Gordon Strachan guided to eighth in 2003 look like?
Liverpool hesitated over signing Virgil Van Dijk from Celtic, which enabled Southampton to do a deal for the centre-back.
Everton are said to be interested in Southampton defender Virgil Van Dijk.
Manchester United fans were impressed as Southampton ace dominated against rivals Liverpool.
West Ham United-linked Moussa Dembele should look at Virgil van Dijk and Victor Wanyama, says Scott Brown.