Not since 1954 had Wales won the championship after losing their opening game.
England have been warned to concentrate on beating Italy before they even start to contemplate a potential grand slam date with Wales next week.
England believe defence will shape their Six Nations grand slam bid as the championship leaders prepare for their final two games against Italy and Wales.
England have put Leicester's Toby Flood on standby to start against Italy next week amid continuing uncertainty over the fitness of the fly-half Owen Farrell.
All problems are relative when you sit unbeaten on top of the Six Nations championship table with an opportunity to win a first grand slam since 2003.