McQueen has filled in at left-back in the absence of Ryan Bertrand and Matt Targett in recent games against Inter Milan and Manchester City.
From James Ward-Prowse to Adam Lallana, Luke Shaw to Calum Chambers, Southampton may well have found their next in line.
The 21-year-old is set to make his full debut for his hometown club in the San Siro this evening.
Saints' manager Claudio Puel handed the youngster his Premier League debut just 14 minutes into Sunday's 3-1 win against Burnley.
Maarten Stekelenburg, Winston Reid, Ashley Williams, David Luiz, Junior Stanislas, Joe Allen, N’Golo Kante, Sam McQueen, Theo Walcott, Eden Hazard and Dele Alli find themselves in Alan Smith’s Premier League Team of the Weekend for The Telegraph.
Southampton overcame Burnley with ease this weekend.
Southampton began their pre-season campaign in fine style with a 4-0 win against Dutch side EHC Hoensbroek in Ronald Koeman's first game.