The Stoke City loanee has been dropped to the reserves.
West Ham United were beaten 3-0 by Southampton on Sunday.
Southampton's Jose Fonte would be a useful signing for Arsenal.
The winger could be set to link up with his former manager Jorge Jesus.
The Italian has no desire to head to Villa Park.
Arsenal midfielder Jack Wilshere is expected to be on the bench next week.
Dutch national coach Louis Van Gaal criticised the style of Manchester United in their dealing with Van Persie and confirmed Premier League interest with Tottenham Hotspur the likely destination.
Now it is the turn of the Youth Team after they were dumped out of the FA Youth Cup with a 4-2 home defeat against Everton.