The Monday night Premier League action sees two north-east teams in need of points line up against each other at the Riverside.
Tottenham Hotspur are currently sat five points behind top of the table Liverpool.
Southampton supporters on Twitter expressed their dismay at their side's 2-1 loss to Premier League strugglers Hull City.
The 17-year-old is one of two options to replace the injured Andy Robertson at left-back.
The Hull City captain is set to make his first appearance of the season against Stoke City this weekend, after helping his manager against Bournemouth.
Tottenham Hotspur lost to Monaco in the Champions League on Wednesday night.
The midfielder left Spurs to become Hull City's record signing on Tuesday.
Michael Dawson spent eight years at Forest before moving to Tottenham Hotspur as a 21-year-old in 2005.
The two sides meet at the Emirates Stadium on Saturday afternoon.
Bournemouth are said to be interested in signing Michael Dawson from Hull.