Denayer has been used in midfield with Sunderland hit by injuries in recent weeks.
O'Shea remains positive about Sunderland despite a 2-0 loss to Liverpool at the weekend.
Sunderland are currently sat at the bottom of the Premier League table, after a disappointing start.
The Black Cats are at the bottom and already eight points away from safety.
Moyes also updated on Vito Mannone, Fabio Borini and Lee Cattermole.
Sunderland were beaten 1-0 by West Ham United courtesy of a late Winston Reid goal.
Sunderland currently have eight first-team players on the treatment table.
Sunderland are bottom of the table and yet to keep a clean sheet this season.
Pickford has been thrust into the action this season following an elbow injury to Vito Mannone.
John O'Shea has made just four appearances for Sunderland so far this season.