The Belgian defender has picked up an injury while on international duty with Belgium Under-21s.
The defender joined Sunderland on loan from Manchester City in the summer transfer window.
Sunderland and West Bromwich Albion played out a 1-1 draw at the weekend.
Sunderland are due to face Tottenham Hotspur in Premier League action this weekend.
Denayer featured in the under-23 game with Rochdale on Tuesday night.
The Belgian teammates have both made loan moves to the Stadium of Light this season.
Sunderland make request to FIFA in an attempt to secure the services of Boavista goalkeeper Mika.
The defender joined on loan from Manchester City on deadline day of the transfer window.
The defender joined in a deadline day move from Manchester City.
Stoke City brought in Wilfried Bony. Pep Guardiola trimmed his Manchester City squad. But for some Premier League clubs, Deadline Day did not go to plan.