West Ham lost 1-0 away at Leicester City on Saturday afternoon.
West Ham United striker Andre Ayew was expected to miss West Ham's big game against Manchester United on Monday.
West Ham United beat Swansea City 4-1 at the Liberty Stadium on Boxing Day.
The former Swansea forward is West Ham United's club-record signing.
West Ham United are enduring a torrid season and will have to make do without three key players for nearly a month in January.
Andre Ayew joined West Ham United from Swansea City in the summer transfer window.
The Hammers lie just above the relegation zone in the Premier League table.
Andre Ayew has made four appearances for West Ham United to date.
He joined West Ham United for a reported £20.5 million in the summer.
West Ham United were beaten 2-0 by Everton on Sunday at Goodison Park.