Pearce was making his third straight appearance as Derby County went down 2-0 against Wolverhampton Wanderers.
Adkins arrives at Hull City following spells at Sheffield United and Reading.
Reading FC haven't been able to reach these heights since.
Shackell has been one of the most consistent second tier defenders in recent seasons - not that Derby need him.
Jason Shackell had been a key member of the starting XI until September but his injury has allowed Alex Pearce to step up.
Manager Steve McClaren is expected to name an unchanged line-up as his Derby County side travel to Molineux to face Wolverhampton Wanderers - for what promises to be an entertaining Championship clash.
Stoke City, Derby County and Aston Villa are all represented.
The Rams continued their improvement under Steve McClaren against Sheffield Wednesday.
Derby County defender Alex Pearce has had his say on new manager Steve McClaren's impact after his first game back in charge.
Derby County drew 1-1 with Bristol City in Saturday's Championship encounter.