Everton face their toughest test yet as they travel to Manchester to take on the league leaders.
The youngster on loan from West Ham scored in Norway's win over San Marino in midweek.
Boro could leapfrog their opponents with a win in the Sunday lunchtime clash at the Riverside.
Leeds have really hit their stride in the build up to the international break with a string of good performances consolidating their league position.
Defoe is Sunderland's top goalscorer so far this season with four.
The Clarets manager expects goalkeeper Tom Heaton to be fit enough for the trip to St Mary's on Sunday.
Rangers are looking to make it back-to-back wins against Inverness Caledonian Thistle this evening.
Aston Villa and Derby County start in the same position under new managers.
West Bromwich Albion host Tottenham Hotspur at the Hawthorns on Saturday.
Crystal Palace host West Ham United at Selhurst Park on Saturday.
After 686 days since his last professional game, the former Swansea City striker Michu finally returned on Thursday evening, but could not prevent Real Oviedo from being knocked out of the Copa Del Rey 4-3 by UCAM Murcia after extra time, despite scoring twice – including a last-minute equaliser.
Landon Donovan has surprised MLS by coming out of retirement to rejoin the LA Galaxy for the rest of the season. The club confirmed the news on Thursday.
The Tottenham Hotspur and Wales fullback has found himself very much second favourite to Danny Rose at White Hart Lane recently.