The Uruguayan striker has been called up by his country despite only recently returning from injury.
The Aston Villa player could be coming to the end of his time at the club.
The Tottenham Hotspur player would not be risked during the international break unless he was fit, according to his national boss.
The Celtic midfielder has been in fine form this season.
The Under 21 boss was quick to praise the young defender's versatility.
HITC Sport understands that the former Aston Villa boss will be returning to management in the Championship at Ewood Park.
The Republic of Ireland goalie played under Pardew at Charlton Athletic.
Jason Holt has scored four times in 17 appearances for Rangers.
The Tottenham Hotspur duo were not in Roy Hodgson's plans at the start of the season, but how quickly things change.
The Toffees have had success with the winger, would the forward be a similar hit.