After narrowly missing out on the playoffs last season, the Earthquakes look like they are primed to take another step forward in 2016.
After injuries ruined their MLS Cup hopes last season, Sporting KC are looking forward to a healthier 2016.
With Kaka, Cyle Larin and Antonio Nocerino leading the way, Orlando look like genuine playoff contenders going into their second season in MLS.
West Brom beat Crystal Palace 3-2 on Saturday night.
The Impact will be hoping that the "Drogba Effect" felt late last season carries over into the new campaign.
After enjoying a run to the Western Conference final last season, Oscar Pareja's youthful side will be aiming to take another big step forward in 2016.
Former West Ham United striker Craig Bellamy says Mark Noble is thriving in his role alongside the fresh talent in the Hammers squad.
Everton are set to take on Aston Villa at Villa Park in midweek.
Derby County lost to Wolverhampton Wanderers in the Championship on Saturday afternoon.
Here is how Manchester United and Arsenal will line up this afternoon:
A promising footballer still looking for his place in the side, but whenever used in a role that looks close to his preferred position, he can look a little lost.
Arsenal will be looking to return to winning ways in the North London derby tomorrow..
Newcastle United will face Sheffield Wednesday in the third round of the League Cup at St. James’ Park tomorrow.