Brendan Rodgers continues to try and lead Celtic to a successful season ahead of a big set of games.
The midfielder has been in fine form for Everton since joining from Aston Villa in the summer.
The full-back may get his chance for Arsenal after an injury to Hector Bellerin.
Jose Mourinho has been given the job of restoring former glories at Manchester United, so how does his start to the season compare to his predecessor's?
The Spurs captain is set to test the salary cap of chairman Daniel Levy.
Leeds United are one of the Championship's form sides at present.
The German boss has been a huge success since arriving at Liverpool last year.
Does Everton manager Ronald Koeman need to learn that honesty is not always the best policy?
Antonio Barragan is starting to come into his own at Middlesbrough following his move to the Riverside in the summer.
The Spurs striker is likely to get his first taste of the eternal rivalry on Friday.